Skipper Cesc Fabregas, Alex Song, Theo Walcott and Abou Diaby all return after missing the 2-2 draw at West Brom in the Gunners' last outing almost a fortnight ago.
Wenger is also optimistic that Robin van Persie, Nicklas Bendtner and Aaron Ramsey will shake off knocks picked up on international duty, but a final decision on the trio will be made after training on Friday.
"[Fabregas, Song, Walcott and Diaby] will all be available," Wenger told ArsenalTV Online. "I have not decided if they will start the game yet but they will all be available.
"Van Persie has a good chance too. He has a final assessment tomorrow (Friday) but we believe he will be fit. It is a bruised knee. Nicklas Bendtner is in the same situation. He will have a test tomorrow on his ankle and we'll see.
"In fact, we have a few players with tests tomorrow - Ramsey with his groin, Bendtner with his ankle, Van Persie with his knee. I will make a decision after training in the morning."
Denilson is the only certain absentee for Rovers' visit after being ruled out with a toe injury.